Cheesy Garlic Biscuit Bubble-Up Casserole

If you love warm, cheesy comfort food with a golden, buttery finish, this Cheesy Garlic Biscuit Bubble-Up Casserole is the kind of recipe you’ll want to keep close. It combines fluffy biscuit pieces, rich garlic butter, plenty of melted cheese, and a creamy savory filling in one bubbling casserole dish.

The best part is how simple it is to prepare. Instead of making biscuits from scratch, refrigerated biscuit dough is cut into bite-sized pieces and layered with the flavorful filling. As everything bakes, the biscuits puff up around the cheesy mixture, creating crispy golden edges and soft, tender centers.

It makes an excellent weeknight dinner, weekend brunch dish, or comforting side for a family gathering.

Why You’ll Love This Casserole

This recipe brings together several things that make comfort food so satisfying:

• Fluffy biscuit pieces that bake right into the casserole
• Garlic butter for a rich, savory flavor
• Melted cheese throughout every bite
• A creamy filling that keeps the casserole moist
• Golden, slightly crisp biscuit tops
• Simple ingredients and minimal preparation
• One-pan convenience, making cleanup easier

You can also customize the recipe with cooked chicken, sausage, bacon, vegetables, or your favorite blend of cheeses.

Ingredients

For the Casserole

• 2 cans refrigerated biscuit dough
• 2 cups shredded mozzarella cheese
• 1 cup shredded cheddar cheese
• 1 cup cooked, chopped chicken
• 1 cup sour cream
• 1 can condensed cream of chicken soup
• ½ cup milk
• 2 tablespoons grated Parmesan cheese
• 2 cloves garlic, minced
• 2 tablespoons melted butter
• 1 teaspoon Italian seasoning
• ½ teaspoon onion powder
• ½ teaspoon salt
• ¼ teaspoon black pepper
• 2 tablespoons chopped fresh parsley, plus more for garnish

Optional Add-Ins

For a heartier casserole, you can add:

• Cooked crumbled sausage
• Crispy bacon
• Diced ham
• Chopped spinach
• Sautéed mushrooms
• Diced bell peppers
• Green onions
• Red pepper flakes for a little heat

Step-by-Step Instructions

Step 1: Preheat the Oven

Preheat your oven to 375°F (190°C).

Lightly grease a 9×13-inch baking dish with cooking spray or a thin layer of butter. Greasing the dish helps prevent the cheesy filling and biscuit pieces from sticking.

Set the prepared baking dish aside while you make the casserole mixture.

Step 2: Prepare the Garlic Butter

Place the melted butter in a small bowl.

Add the minced garlic and stir well. Mix in about half of the chopped parsley.

Let the mixture sit for a few minutes. This gives the garlic time to flavor the butter.

The garlic butter will eventually be brushed over the biscuit pieces, giving them a deliciously savory, golden crust.

Step 3: Cut the Biscuits

Open the refrigerated biscuit dough and separate the biscuits.

Cut each biscuit into approximately 6–8 bite-sized pieces.

Try to keep the pieces relatively similar in size so they bake evenly.

Place the cut biscuit pieces in a large mixing bowl and gently toss them with about half of the garlic butter mixture.

Don’t worry if the biscuit pieces aren’t completely coated. They’ll pick up additional flavor as they bake with the casserole.

Step 4: Make the Creamy Filling

In a separate large bowl, combine:

• Sour cream
• Cream of chicken soup
• Milk
• Italian seasoning
• Onion powder
• Salt
• Black pepper
• Parmesan cheese

Stir until everything is smooth and well combined.

Add the cooked chopped chicken and mix again.

The result should be a thick, creamy mixture with the chicken evenly distributed throughout.

Step 5: Add the Cheese

Add approximately 1½ cups of the mozzarella and ¾ cup of the cheddar to the creamy chicken mixture.

Fold everything together gently.

Save the remaining cheese for the top of the casserole. Reserving some cheese gives the finished dish that beautiful bubbling, golden layer.

Step 6: Assemble the Casserole

Spread about half of the biscuit pieces across the bottom of the prepared baking dish.

Spoon the creamy chicken mixture over the biscuits.

Use the back of a spoon or spatula to gently spread the filling into an even layer.

Add the remaining biscuit pieces over the top.

It’s perfectly fine if some pieces sit partially above the filling. Those exposed pieces will become beautifully golden as they bake.

Step 7: Add More Cheese and Garlic Butter

Sprinkle the remaining mozzarella and cheddar evenly over the casserole.

Drizzle or brush the remaining garlic butter over the exposed biscuit pieces.

For even more flavor, sprinkle a little additional Parmesan and Italian seasoning over the top.

At this point, the casserole should be generously covered with cheese and dotted with buttery garlic flavor.

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