Chicken Bubble Biscuit Bake Casserole: A Comforting Family Favorite

When it comes to warm, hearty, and fuss-free meals, a Chicken Bubble Biscuit Bake Casserole checks all the boxes. This cozy dish combines tender chunks of chicken, creamy sauce, melted cheese, and fluffy biscuits that bake into golden perfection. It’s the kind of meal that brings everyone to the table, perfect for busy weeknights, potlucks, or a weekend comfort-food dinner.

In this recipe, refrigerated biscuit dough does the heavy lifting, giving you soft, pillowy bites throughout the casserole without the need for homemade bread-making. The creamy chicken mixture is simple yet flavorful, and everything comes together in one baking dish. Let’s dive into how you can make this step by step.

Ingredients You’ll Need

3 cups cooked chicken, shredded or cubed (rotisserie chicken works great)
2 cups frozen mixed vegetables (peas, carrots, corn, green beans)
1 can (10.5 oz) cream of chicken soup
1 cup sour cream (or plain Greek yogurt for a lighter version)
1 teaspoon garlic powder
1 teaspoon onion powder
½ teaspoon dried thyme or Italian seasoning
Salt and black pepper to taste
1½ cups shredded cheddar cheese (divided)
1 can (16 oz) refrigerated biscuits (buttermilk or homestyle)
2 tablespoons melted butter (optional, for brushing the biscuits)

Step-by-Step Instructions

Step 1: Prepare the Chicken Mixture

In a large mixing bowl, combine the shredded chicken, cream of chicken soup, sour cream, mixed vegetables, and half of the shredded cheese. Season with garlic powder, onion powder, thyme, salt, and pepper. Stir everything together until well coated in the creamy sauce.